People taking tirzepatide, the active ingredient in Zepbound and Mounjaro, may see better weight-loss results when they pair the medication with a clear personal goal, according to new research presented at ENDO 2026. The study also found differences by sex, with women generally losing more weight than men.

What the Study Found

The analysis included 80,942 adults starting tirzepatide. Follow-up data were available for 21,490 people at 6 months and 4,429 at 12 months, although most participants were still in follow-up when the results were reported. In this observational study, people who set a weight-loss target at baseline, or who had previously tried structured diet plans, tended to achieve greater weight loss.

Researchers also reported that participants with certain pre-existing conditions, including metabolic dysfunction-associated liver disease, were less likely to reach a 20% total body-weight loss target by 12 months.

Why Goal Setting May Matter

Experts who were not involved in the research said the results fit with broader behavioral science: a specific goal can help people stay focused, track progress, and maintain motivation. In the context of GLP-1 medications, goal setting may complement the appetite-related effects of the drug by supporting day-to-day habits and consistency.

Because the findings have not yet been published in a peer-reviewed journal, they should be viewed as preliminary. People considering or already using GLP-1 treatment should discuss expectations and follow-up care with a qualified clinician.

Takeaways From the Presentation

• People with a personal weight-loss goal tended to lose more weight on tirzepatide.
• Women in the study were more likely than men to reach larger weight-loss milestones.
• Participants with prior structured diet attempts also did better on average.
• The results were presented at a conference and are not yet peer reviewed.

Researchers and clinicians suggested that combining medication with realistic goals and behavioral support may help tailor care to individual needs, especially for people who may face motivational barriers.